3rd most populous of 82
With 195,871 residents in 2024, DeSoto County ranks 3rd by population among Mississippi's 82 counties and is home to 6.7% of the state's residents.

DeSoto County has the highest median household income in Mississippi ($85,297) and the lowest poverty rate (9.7%).
DeSoto County is home to 195,871 people (2024 estimate) on 476 square miles of land. This page brings together official U.S. Census Bureau population estimates since 2000, the components of change—births, deaths and migration—American Community Survey indicators on income, housing, poverty and education, BEA economic accounts and BLS unemployment.
Pick an indicator to see its long-run evolution.
U.S. Census Bureau: intercensal estimates 2000–2009, Vintage 2020 (2010–2019) and Vintage 2024 (2020–2024), July 1.
| Indicator | Value | Year and source |
|---|---|---|
| Population estimate | 195,871 | 2024 · U.S. Census Bureau |
| Population, 2010 Census | 161,252 | 2010 · U.S. Census Bureau |
| Population, 2000 | 108,714 | July 1, 2000 · Census intercensal |
| Change since 2000 | +80.2% | 2000–2024 · Census |
| International migration | +254 | 2024 · Census Vintage 2024 |
| Domestic migration | +1,843 | 2024 · Census Vintage 2024 |
| Birth rate | 8.5 per 1,000 | 2024 · calculated |
| Death rate | 9.3 per 1,000 | 2024 · calculated |
| Population rank in Mississippi | 3rd of 82 | 2024 · calculated |
| Per capita personal income | $57,305 | BEA, 2024 · official |
| Gross domestic product | $9.8 billion | BEA, current dollars, 2024 · official |
| Median household income | $85,297 | ACS 2020–2024 5-year · official |
| Poverty rate | 9.7% | ACS 2020–2024 5-year · official |
| Bachelor’s degree or higher | 29.0% | Age 25+, ACS 2020–2024 5-year · official |
| Foreign-born residents | 4.0% | ACS 2020–2024 5-year · official |
| Median home value | $269,600 | ACS 2020–2024 5-year · official |
| Median gross rent | $1,451/month | ACS 2020–2024 5-year · official |
| Median age | 37.3 years | ACS 2020–2024 5-year · official |
| Households | 70,986 | ACS 2020–2024 5-year · official |
| Owner-occupied homes | 77.9% | ACS 2020–2024 5-year · official |
Comparable indicators for DeSoto County, Mississippi and the United States.
| Indicator | County | Mississippi | U.S. | Reference |
|---|---|---|---|---|
| Population change 2020–2024 | +5.7% | −0.6% | +2.6% | Census Vintage 2024 |
| Birth rate (per 1,000) | 8.5 | 11.5 | 10.6 | 2024 |
| Death rate (per 1,000) | 9.3 | 12.2 | 9.1 | 2024 |
| Net migration rate (per 1,000) | 10.7 | 0.6 | 8.2 | 2024 |
| Population density (/mi²) | 411.2 | 62.7 | 96.3 | 2024 |
| Per capita personal income | $57,305 | $52,074 | $73,204 | BEA, 2024 |
| Median household income | $85,297 | $56,447 | $80,734 | ACS 2020–2024 5-year |
| Poverty rate | 9.7% | 18.9% | 12.5% | ACS 2020–2024 5-year |
| Bachelor’s degree or higher | 29.0% | 25.1% | 35.7% | Age 25+, ACS 2020–2024 5-year |
| Foreign-born residents | 4.0% | 2.4% | 14.1% | ACS 2020–2024 5-year |
| Median home value | $269,600 | $169,800 | $332,700 | ACS 2020–2024 5-year |
| Median gross rent | $1,451/month | $954/month | $1,413/month | ACS 2020–2024 5-year |
| Median age | 37.3 years | 38.6 years | 38.9 years | ACS 2020–2024 5-year |
| Owner-occupied homes | 77.9% | 70.0% | 65.2% | ACS 2020–2024 5-year |
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With 195,871 residents in 2024, DeSoto County ranks 3rd by population among Mississippi's 82 counties and is home to 6.7% of the state's residents.
Its population went from 108,714 in 2000 to 195,871 in 2024, a change of +80.2%, compared with +3.3% for Mississippi as a whole.
In the year to July 2024 the county recorded 1,659 births and 1,825 deaths, so deaths outnumbered births by 166.
Annual Census estimates since 2000 put the county's highest population in 2024, at 195,871.
DeSoto County has about 411.2 residents per square mile of land, ranking 1st of 82 counties; Mississippi averages 62.7.
With a median household income of $85,297 (ACS 2020–2024 5-year), the county ranks 1st of 82 Mississippi counties; the state median is $56,447.
Its economy produced $9.8 billion of GDP in 2024 (BEA), 6th largest among 82 Mississippi counties.
Real GDP grew 4.7% in 2024, adjusted for inflation (BEA, chained 2017 dollars).